Maternal-Fetal Medicine Physician; Assistant Professor, Tufts University School of Medicine
Department + Services
Obstetrics and Gynecology, Maternal-Fetal Medicine (High-Risk Pregnancy)
Clinical Focus Areas
High-risk pregnancy, biomechanics, ultrasound
Dr. House’s research focus is on studying the role of the cervix in normal and high-risk pregnancy. Normal cervical function is critical for a healthy pregnancy but premature cervical shortening and dilation is associated with preterm birth, which affects 12% of pregnancies in the United States. Research activities include 1) design and evaluation of three-dimensional models of cervical tissue to study remodeling of the cervical extracellular matrix, 2) investigation of the cervical biomechanical function using mechanical modeling techniques, 3) study of the barrier properties of cervical mucus as it relates to protection against intrauterine infection and 4) development of novel therapies such as injectable biomaterials to augment cervical function during pregnancy. This research is valuable for understanding why the cervix stays closed in normal pregnancy but shortens and opens in preterm birth. Successful accomplishment of this research relies on a collaborative multidisciplinary research team involving investigators with expertise in mechanical engineering, biology and maternal fetal medicine.